MICROBIAL GENE REGULATION
 
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OUR LAB

Bacterial gene control is a dynamic process involving the interplay of various regulatory factors. We are interested to understand the molecular mechanisms underlying gene expression control in microbial pathogens focussing on the role of regulatory RNAs. Further, we are interested in studying the regulatory players involved in microbial communication processes (e.g. Quorum Sensing) and how these shape complex behaviors such as biofilm formation and dispersal. The Papenfort laboratory was previously located at the LMU in Munich (Germany) and has moved to the University of Jena (Germany) in Fall  2019.          

RESEARCH

Click on the icons to learn more about the individual research foci.

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RNA BIOLOGY OF
BACTERIAL PATHOGENS

SYSTEMS BIOLOGY OF

BACTERIAL SMALL RNAS

SYNTHETIC
RNA REGULATORS

Regulatory principles of small RNAs in bacterial pathogens, such as Vibrio cholerae

Artificial RNA regulators
for specific tasks
in 
bacteria

Influence of regulatory RNAs on heterogenous gene expression in bacteria

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BACTERIAL
COMMUNICATION

REGULATORY RNAS IN
CAULOBACTER

Molecular mechanisms of quorum sensing in

Vibrio cholerae

Principles of RNA-mediated gene expression control in alpha-proteobacteria

PUBLICATIONS

A complete list of publications can be found on NCBI:

 

TEAM

JOBS

POSTDOC AND PHD OPPORTUNITIES

We are currently looking for motivated Postocs and PhD students to join our team.

If you are interested, please send your application (including a motivation letter, CV, and a list of publications) to Prof. Dr. Kai Papenfort at kai.papenfort@uni-jena.de 

 
 
 

NEWS

Our work on regulatory RNAs in entomopathogenic bacteria is now online at Nature Microbiology. Great collaboration with the Bode lab at the University of Frankfurt.

New work is now out in eLIFE. We discovered a new concept in bacterial gene regulation in which small regulatory RNAs can serve as autoregulatory elements.

Our newest work on regulatory RNAs and Hfq in Vibrio cholerae is now online at PNAS.

Kai was selected as one of five 2019 Vallee Scholars.

Check out our new paper on microbial small RNAs in The EMBO Journal. Our work shows that the small RNAs MicV and VrrA act as global regulators in the envelope stress response of Vibrio cholerae and provide evidence that bacterial sRNAs can be functionally annotated by their seed-pairing sequences.

Kai was awarded a Starting Grant by the European Research Council as one of five young researchers at the LMU.

 

CONTACT

PAPENFORT LAB

Friedrich Schiller University of Jena

Institute of Microbiology

Chair of General Microbiology

BIZ, M1E3

Winzerlaer Straße 2, 07745 Jena

GERMANY

PROF. DR. KAI PAPENFORT

University Professor

kai.papenfort@uni-jena.de 

+49 (0)3641 / 9395753 (Phone)

+49 (0)3641 / 949312 (Fax)

 
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